Implications of sterol structure for membrane lipid composition, fluidity and phospholipid asymmetry inSaccharomyces cerevisiae

Relationship between ethanol tolerance, lipid composition and plasma membrane fluidity in Saccharomyces cerevisiae and Kloeckera apiculata.

The lipid composition of a strain of each of two yeasts, Saccharomyces cerevisiae and Kloeckera apiculata, with different ethanol tolerances, was determined for cells grown with or without added ethanol. An increase in the proportion of ergosterol, unsaturated fatty acid levels and the maintenance of phospholipid biosynthesis seemed to be responsible for ethanol tolerance. The association of et...

Lipid Composition and Membrane Fluidity of Butanol-Tolerant

The effect of butanol challenge (0, 1.0, 1.5% [vol/vol]) and growth temperature (22, 37, 42°C) on the membrane composition and fluidity of Clostridium acetobutylicum ATCC 824 and a butanol-tolerant mutant, SA-2, was examined in chemically defined medium. Growth of strain ATCC 824 into the stationary phase coincided with a gradual increase in the percent saturated to percent unsaturated (SU) fat...

Membrane phospholipid asymmetry counters the adverse effects of sterol overloading in the Golgi membrane of Drosophila.

Cholesterol and phospholipids serve as structural and functional components of cellular membranes in all eukaryotes. Heterogeneity in cholesterol and phospholipid content both within and between different organelles is an important characteristic of eukaryotic membranes. How this heterogeneity is achieved and orchestrated to maintain proper cellular physiology remains poorly understood. We prev...

Plasma membrane phospholipid asymmetry.

Pathophysiologic implications of membrane phospholipid asymmetry in blood cells.

M tivities seem to work in concert to maintain a nonrandom ANY STUDIES HAVE led to the concept that membrane phospholipid asymmetry is ubiquitous. In gentransbilayer phospholipid orientation. Inhibition of these aceral terms, the outer leaflet of eukaryotic plasma membranes tivities stops lipid movement, but it does not result in loss is formed predominantly with the cholinephospholipids of asy...